This guide serves as an essential resource for researchers, university students, collaborators, and new team members, offering a concise introduction to peptide design, synthesis, and handling.

Whether you’re advancing groundbreaking research or exploring therapeutic innovation, Bachem is here to support your onward journey in the dynamic world of peptides. Explore career opportunities with Bachem and become part of a community of world-class professionals with unparalleled chemical knowledge and a shared passion for innovation.

We’ll cover the basics of peptides, their importance, and applications. You’ll learn about amino acids, their structure, and how they influence peptide properties. We’ll also explain amino acid notations and derivatives, providing the foundation for understanding peptide synthesis and its role in various industries.

In this section, we’ll explore the fundamentals of peptides, including their definition and significance. We’ll also delve into amino acids, examining their structures and how these influence the properties of peptides. Additionally, we’ll cover the notations used for amino acids and discuss their derivatives.

This section explores four peptide synthesis methods: Solid-Phase Peptide Synthesis (SPPS), Liquid-Phase Peptide Synthesis (LPPS), Molecular Hiving™, and Chemo-enzymatic Peptide Synthesis (CEPS). Discover how Bachem employs these techniques, combining traditional methods with innovative approaches developed through industry partnerships.

Bachem outlines the peptide purification process, including impurity removal, standard RP-HPLC purification, and alternatives for challenging peptides. It addresses scalability using methods like CCD, the impact of basic groups on salt formation, and introduces MCSGP technology, offering improved efficiency, sustainability, and higher yields in peptide manufacturing.

This chapter focuses on the quality control (QC) processes for peptide products post-purification and lyophilization. It covers methods to confirm product identity, purity, and content, including techniques like TLC, HPLC, and mass spectrometry. It also addresses batch variability, handling of residual contaminants, and recommended purity levels for different applications.